中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2015, 27(2): 198-202
BRCA2的BRC4基元与RAD51相互作用位点的研究进展
赵东欣1*,李林彬1,卢 奎1,2*,马 丽1,何 娟1
(1 河南工业大学化学化工学院,郑州 450001;2 河南工程学院,郑州 451191)
摘 要:乳腺癌易感基因2 (breast cancer susceptibility gene 2, BRCA2),是人体内一种与乳腺、卵巢、胰腺等部位的肿瘤有关的抑癌基因。人的RAD51 (hRAD51) 是参与DNA 同源重组修复过程的关键蛋白。BRCA2 蛋白通过其结构中8 个高度保守的BRC 重复基元来调控hRAD51 通过同源重组对DNA 损伤进行的修复,从而阻止细胞癌变。在BRCA2 的8 个BRC 重复基元中,BRC4 与同源重组酶hRAD51 的相互作用较为明显。综述了BRCA2 的BRC4 基元与hRAD51 相互作用位点的研究进展,为了解BRCA2 与RAD51相互作用的分子机理提供基础。
 
Research progresses on the interaction sites between BRC4 motif of BRCA2 and RAD51
ZHAO Dong-Xin1*, LI Lin-Bin1, LU Kui1,2*, MA Li1, HE Juan1
(1 School of Chemistry and Chemical Engineering, Henan University of Technology, Zhengzhou 450001, China; 2 Henan Institute of Engineering, Zhengzhou 451191, China)
Abstract: Breast cancer susceptibility gene 2 (BRCA2) is a tumor suppressor gene which is related to different cancers, such as breast, ovarian, pancreatic cancer. Human RAD51 (hRAD51) protein plays a crucial role in homologous recombination. BRCA2 interacts directly with RAD51 through eight highly conserved BRC motifs and stimulates the exchange of RAD51-mediated DNA strand in DNA double-strand breaks repair. BRC4 motif shows stronger binding ability to human RAD51 than the other BRC repeats. In order to better understand the molecular interactions between BRCA2 and RAD51, the research progresses on the binding sites of BRC4 and hRAD51 were summarized here.
 
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