中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2015, 27(2): 120-126
肿瘤免疫组库研究促进癌症疫苗研究
张 蒙1,王倚天1,谢良富1,蔡志明1*,吴 松1,2*
(1 安徽医科大学深圳市第二人民医院临床医学院,深圳 518000;2 中山大学中山医学院,广州 510000)
摘 要:人体免疫系统是抵御病原菌侵犯、防止肿瘤发生最重要的保卫系统。针对免疫系统中T/B 淋巴细胞的免疫组库研究,找出肿瘤与TCR 或BCR 之间的关系,发现肿瘤特异性标志物,从而推动肿瘤特异性诊断、治疗及预后评估等的发展,特别是在肿瘤免疫组库研究基础上衍生出的癌症疫苗,可以在患者体内实现诱导定向肿瘤免疫反应,为肿瘤患者的治疗带来新希望。现从肿瘤免疫组库、癌症疫苗的研究进展等方面来阐述。
 
Tumor immune repertoire study promotes the research of tumor vaccine
ZHANG Meng1, WANG Yi-Tian1, XIE Liang-Fu1, CAI Zhi-Ming1*, WU Song1,2*
(1 Shenzhen Second People's Hospital, Clinical Medicine College of Anhui Medical University, Shenzhen 518000, China; 2 Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510000, China)
Abstract: The immune system plays a vital role in the prevention of pathogen invasion and tumor development. The immune repertoire study, which targets T/B lymphocytes, can propel the development of tumor-specific diagnosis, treatment, evaluation of prognosis with the discovery of tumor-specific biomarkers after the correlation between tumor and TCR/BCR is elucidated. The tumor vaccine, derived from the tumor immune repertoire study, can induce a tumor-oriented immune response in patients, thus providing a new treatment for cancer. In this paper, we conducted a systematic review on the tumor immune repertoire study and demonstrated the advance in tumor vaccine research.
 
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