中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2014, 26(11): 1222-1228
miR-26家族与肿瘤关系的研究进展
刘 放1,高晓健1,陆 霞1,张婷婷1,李墨林2*
(1 大连医科大学2010级七年制,大连 116044;2 大连医科大学病理生理学教研室,大连 116044)
摘 要:miR-26 家族是由miR-26a、miR-26b、miR-1297 及miR-4465 等序列相似、结构相仿、种子区序列相同(UCAAGUA) 的微小RNA(microRNAs, miRNAs) 组成。多种组织细胞分化过程中伴有miR-26 家族表达的增加,其异常表达与特发性肺纤维化、原发性胆汁性肝硬化、多发性硬化及阿尔茨海默病等有关。近年研究报道,多种肿瘤组织亦存在miR-26 基因表达紊乱,并与肿瘤的发生发展密切相关。就miR-26 家族及其调控的靶基因与肿瘤关系的研究进展进行综述。
 
Progress on the relationship between miR-26 family members
    and malignant tumors
LIU Fang1, GAO Xiao-Jian1, LU Xia1, ZHANG Ting-Ting1, LI Mo-Lin2*
(1 Grade 2010, Seven-year Program of Clinical Medicine, Dalian Medical University, Dalian 116044, China; 2 Department of Pathophysiology, Dalian Medical University, Dalian 116044, China)
Abstract: miR-26 family is composed of 4 miRNAs, including miR-26a, miR-26b, miR-1297 and miR-4465, which share same seed region (UCAAGUA) and similar sequence and structure. It is known the expression of miR-26 members was increased during osteogenic differentiation, smooth muscle cell (SMC) differentiation and neurogenesis, and etc. The disturbance of miR-26 family gene expression was related with biliary cirrhosis, pulmonary fibrosis, multiple sclerosis and Alzheimer’s disease, etc. It was reported recently the disturbance of miR-26 expression existed in tumors and it might play an important role in tumorigenesis and tumor development. In this review, the progress on the relationship between miR-26 family and their target genes and malignant tumors are summarized.
 
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