中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2014, 26(11): 1207-1214
Survivin小分子抑制剂的研究进展
赵 楠,赵晓航,许 杨*
(中国医学科学院肿瘤研究所,分子肿瘤学国家重点实验室,北京 100021)
摘 要:Survivin 是凋亡抑制蛋白家族的一员,在抑制细胞凋亡、调控细胞周期、参与血管形成等方面发挥重要的生物学功能。Survivin 在多种肿瘤组织中过量表达,与肿瘤不良预后和耐药性密切相关。Survivin作为一种潜在的肿瘤治疗靶点,其小分子抑制剂用于肿瘤治疗的研究为人们所关注。概述了Survivin 的结构、功能及其在肿瘤组织中的特异性表达,综述了目前靶向Survivin 的小分子抑制剂的研究进展。
 
Advance in small-molecule inhibitors of Survivin
ZHAO Nan, ZHAO Xiao-Hang, XU Yang*
(State Key Laboratory of Molecular Oncology, Cancer Institute, Chinese Academy of Medical Sciences,Beijing 100021, China)
Abstract: Survivin is a member of inhibitor of apoptosis protein (IAP) family. It plays a critical biological role in many aspects including inhibiting apoptosis, regulating cell cycle and angiogenesis. Overexpression of Survivin exists in a variety of tumors, which is associated with the poor prognosis and drug resistance. As a potential target for cancer treatment, the small-molecule inhibitors of Survivin is becoming the hot point. This review provides a brief overview about Survivin structure, function, distribution in tumor, and a summary of the current progress of small-molecule inhibitors targeting Survivin.
 
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