中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2014, 26(11): 1176-1186
组蛋白修饰在染色质复制过程中的作用
张 旭,李 晴*
(北京大学生命科学学院,北京大学-清华大学生命科学联合中心,蛋白质和植物基因研究国家重点实验室,北京 100871)
摘 要:真核生物中的DNA 复制,不但要保证DNA 编码的基因组信息高保真复制,也要保证染色质结构所蕴含的表观遗传组稳定传递,这个过程对于维持基因组的完整性和稳定性至关重要。时至今日,人们对DNA 复制的机制已经有了深入的认识,但是对染色质复制以及表观遗传信息传递的了解才刚刚开始。组蛋白是染色质结构中最主要的蛋白组成部分,其上面丰富的转录后修饰是表观遗传调控的核心方式之一。从最近几年组蛋白的修饰研究进展入手,主要综述在DNA 复制过程中组蛋白修饰如何参与染色质复制的调控。
 
A role of histone modifications during chromatin replication
ZHANG Xu, LI Qing*
(State Key Laboratory of Protein and Plant Gene Research, Peking-Tsinghua Center for Life Sciences, College of Life Sciences, Peking University, Beijing 100871, China)
Abstract: In eukaryotic cells, not only the genetic information encoded in DNA, but also the epigenetic information embedded in chromatin organization must be faithfully propagated to the daughter cells during mitosis. Therefore, chromatin replication is an essential process, which is critical for the maintenance of genome stability. While significant progress has been made in elucidating the mechanisms underlying DNA synthesis, the understanding of how DNA is assembled into chromatin during DNA replication is just started. Histones, the major protein components of DNA wrapping into chromatin, are customized with various covalent modifications and play a central role during epigenetic regulation. In this review, we will focus on how histone modifications function in the process of chromatin replication.
 
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