中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2014, 26(11): 1108-1119
真核细胞DNA复制叉稳定性维持机制的研究进展
刘 阳1,孙静亚2,孔道春1*
(1 北京大学生命科学学院,蛋白质与植物基因研究国家重点实验室,北京 100871;
    2 浙江海洋学院海洋科学与技术学院,环境科学系,舟山 316004)
摘 要:DNA 复制是细胞最基本的生命活动之一,是生物体生存和繁殖的基础。从原核生物到真核生物,DNA 复制过程基本保守,分为复制起始和延伸两个阶段。复制叉是DNA 复制的基本结构,它容易遭受多种内源或外源的DNA 复制压力影响而停顿,导致基因组不稳定,引起细胞凋亡、癌变或细胞死亡等严重后果。为了维持复制叉的稳定,细胞进化出了一系列机制,其中最重要机制之一便是S 期细胞周期检验点。就影响DNA 复制叉稳定的内外因素、S 期细胞周期检验点与复制叉稳定性的关系以及复制叉稳定性与相关疾病的发生、治疗等问题进行简要综述。
 
The progress in the mechanistic studies of maintaining replication fork stability in eukaryotic cells
LIU Yang1, SUN Jing-Ya2, KONG Dao-Chun1*
(1 The National Key Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China; 2 Department of Environmental Science, College of Marine Science, Zhejiang Ocean
    University, Zhoushan City 316004, China)
Abstract: Chromosomal DNA replication is one of the most fundamental biological events, all cell or organism growth bases on DNA replication. From prokaryotes to eukaryotes, the basic processes of DNA replication are relatively conserved and divided into two major events, DNA replication initiation and extension. Replication forks are a basic structure of DNA replication and vulnerable to internal and external factors such as DNA lesion, high order of chromatin structure, DNA secondary structure etc. These factors could cause fork pausing and fork collapse, which subsequently results in genomic instability, cancer or cell death. In order to stabilize stalled forks,cells have developed a series of regulation systems, one of which is checkpoint. This article will give a brief review related to fork pausing, fork stabilization and checkpoint control.
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第2877624 位访问者,欢迎!