中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2014, 26(10): 1057-1066
肿瘤转移抑制基因BRMS1的表达分析及机制研究进展
刘雪妮,田 恬,乔晓京,乔守怡*,吴燕华*
(复旦大学生命科学学院,上海 200433)
摘 要:乳腺癌转移抑制基因1 (BRMS1) 是一个有活性的肿瘤转移抑制基因,参与抑制乳腺癌、黑素瘤、鼻咽癌、非小细胞肺癌、卵巢癌等恶性肿瘤的转移。BRMS1 编码蛋白主要通过转录调控转移相关靶基因,参与调节细胞凋亡、细胞通讯、肿瘤血管新生等多种细胞事件。从BRMS1 基因的分子结构、表达调控、生物学功能以及转移抑制机理等方面对BRMS1 的研究进展做简要回顾。
 
Research progress on the expression analysis and mechanism
    exploration of tumor metastasis suppressor gene BRMS1
LIU Xue-Ni, TIAN Tian, QIAO Xiao-Jing, QIAO Shou-Yi*, WU Yan-Hua*
(School of Life Sciences, Fudan University, Shanghai 200433, China)
Abstract: Breast cancer metastasis suppressor 1 (BRMS1) has been demonstrated to be an active metastasis suppressor gene, showing metastasis suppressive role in breast cancer, melanoma, nasopharyngeal carcinoma, non-small cell lung cancer, ovarian cancer, and etc. It has been revealed that BRMS1 protein is able to transcriptionally regulate metastasis-related genes, further to regulate multiple cell events including cell apoptosis, cell communication, tumor angiogenesis, and etc. Herein, the molecular structure, expressional regulation, biological function and metastasis suppression mechanism of BRMS1 gene are briefly reviewed.
 
首页 | 刊物简介 | 编委会 | 投稿须知 | 广告业务 | 过刊浏览 | 联系我们
中国科学院上海生命科学信息中心《生命科学》编辑部
Copyright © 2012-2015 《生命科学》编辑部 All Rights Reserved.
沪ICP备05033115号-30
您是第3064035 位访问者,欢迎!