中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2014, 26(8): 852-857
O-GlcNAc修饰对蛋白质泛素化降解途径的影响
周 丰1,刘晓燕2,王玉秋2,张连文2*
(1 天津大学药物科学与技术学院,天津 300072;2 南开大学药学院,天津 300071)
摘 要:O-GlcNAc 修饰是一种特殊的糖基化修饰,几乎参与生物体内所有细胞过程的调控。该修饰与泛素化作为两种重要的蛋白质翻译后修饰形式,都与2 型糖尿病、神经退行性疾病、癌症等疾病密切相关。O-GlcNAc 修饰对蛋白质泛素化降解途径的影响主要体现在4 个方面:(1) O-GlcNAc 修饰能够抑制26S 蛋白酶体的ATPase 活性;(2) O-GlcNAc 修饰会减少某些底物蛋白的泛素化降解;(3) O-GlcNAc 修饰泛素化相关酶并调节其功能;(4) 某些蛋白质( 包括调控因子) 发生O-GlcNAc 修饰后间接影响蛋白质泛素化。
 
O-GlcNAcylation influences ubiquitin proteasome degradation of protein
ZHOU Feng1, LIU Xiao-Yan2, WANG Yu-Qiu2, ZHANG Lian-Wen2*
(1 School of Pharmaceutical Science and Technology, Tianjin Universtiy, Tianjin 300072, China;2 College of Pharmacy, Nankai University, Tianjin 300071, China)
Abstract: O-GlcNAcylation is a special protein glycosylation, which plays crucial roles in various cellular events.Both O-GlcNAcylation and ubiquitination are important post-translational modification. They are closely related to type 2 diabetes, neurodegenerative diseases, cancer and other diseases. The cross-talk between O-GlcNAcylation and ubiquitination could be divided into four categories: (1) O-GlcNAcylaion of the 26S proteasome regulatory subunit inhibits its ATPase activity; (2) O-GlcNAcylaion on some proteins could decrease their ubiquitin proteasome degradation; (3) O-GlcNAcylation of ubiquitination enzymes regulates their functions; (4) O-GlcNAcylation on some protein (including regulatory factors) affects ubiquitination process indirectly.
 
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