中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2014, 26(7): 756-761
miR-92a家族与肿瘤关系的研究进展
李墨林1,关兴芳2,孙宇强3,李传刚4,王 雪5,舒晓宏5*
(1 大连医科大学病理生理学教研室,大连 116044;2 大连医科大学2010级医疗系,大连 116044;3 大连医科大学2009级七年制,大连 116044;4 大连医科大学附属二院泌尿外科,大连 116023;5 大连医科大学药学院,大连 116044)
摘 要: miR-92a 家族基因是由miR-25、miR-92a~1、miR-92a~2 和miR-363 等序列相似、结构相仿、种子区序列相同的微小RNA (microRNAs) 组成,它们分别来自在进化过程中高度保守并互为旁系同源序列的miR-106b~25、miR-17~92 和miR-106a~363 基因簇。目前研究认为,miR-92a 家族基因是一组与血管内皮细胞形成有关的miRNAs,其表达紊乱与肿瘤的发生发展密切相关。就miR-92a 家族基因及其靶基因与肿瘤关系的研究进展进行综述。
 
Progress of miR-92a family in tumorigenesis
LI Mo-Lin1, GUAN Xing-Fang2, SUN Yu-Qiang3, LI Chuan-Gang4, Wang Xue5, SHU Xiao-Hong5*
(1 Department of Pathophysiology, Dalian Medical University, Dalian 116044, China; 2 Grade 2010, Clinical Medicine, Dalian Medical University, Dalian 116044, China; 3 Grade 2009, Seven-year Program of Clinical Medicine, Dalian Medical University, Dalian 116044, China; 4 Division of Urology, Department of Surgery, the Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China; 5 College of Pharmacy, Dalian Medical University, Dalian 116044, China)
Abstract: miR-92a family is composed of 4 miRNAs in cluding miR-25, miR-92a~1, miR-92a~2 and miR-363, which share same seed region and similar sequence and structure. They arise from three different paralog clusters miR-17~92, miR-106a~363, and miR-106b~25 that are highly conserved in the process of evolution. It was thought that miR-92a family was a group of miRNA correlated with formation of endothelial cells. It was demonstrated that the disturbance of the expression of miR-92a family was related with tumorigenesis and tumor development. In this review, the progress of the relationship between miR-92a family and their target genes and malignant tumors is summarized.
 
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