中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
“健康与疾病的免疫”国际学术研讨会通知      关于有网站冒充本刊网站的声明
《生命科学》 2014, 26(6): 657-664
多发性硬化和视神经脊髓炎的体液免疫机制及其干预策略
徐 雁,崔丽英*
(中国医学科学院北京协和医院神经科,北京100730)
多发性硬化 (multiple sclerosis, MS) 和视神经脊髓炎(neuromyeltis optica, NMO) 是两个独立的中枢神经系统炎性脱髓鞘疾病,B 细胞和体液免疫在二者发生发展中发挥了重要作用。越来越多证据显示,针对B 细胞和/ 或抗体的治疗有可能同时对抗MS 和NMO。就B 细胞及其体液免疫在MS 和NMO 发生发展及治疗中的作用做一综述。
 
The role of humoral autoimmunity in multiple sclerosis and neuromyelitis optica and therapeutic strategy
XU Yan, CUI Li-Ying*
(Department of Neurology, Peking Union Medical College Hospital, Beijing 100730, China)
Multiple sclerosis (MS) and neuromyelitis optica (NMO) are two different inflammatory demyelinating diseases in central nervous system. B cells and humoral immune responses play an important role in the immunopathogenesis of MS and NMO. There is growing evidence that treatments specifically targeting B cells and/or antibodies are effective in both MS and NMO. This review therefore aims to summarize the present knowledge and to outline future directions about the role of B cells and antibodies in research and therapy of MS and NMO.
 
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