中国科技核心期刊
CN:31-1600/Q
ISSN:1004-0374
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《生命科学》 2014, 26(4): 414-418
AI-2/LuxS群体感应系统介导乳酸杆菌益生特性研究进展
姜黎明,康子腾,柳陈坚,李晓然,罗义勇*
(昆明理工大学生命科学与技术学院,昆明 650500)
群体感应(quorum sensing, QS) 是细菌间通过化学信号分子进行信息传递的一种形式。信号分子可以分为4 大类:寡肽(oligopeptides)、酰基高丝氨酸内酯(acyl-homoserine lactone, AHL)、自体诱导物2(autoinduction-2, AI-2) 和扩散信号因子(diffusible signal factor, DSF),其中AI-2 和其生物合成关键酶LuxS组成的QS 系统(AI-2/LuxS 系统) 介导革兰氏阳性(G+) 和阴性(G-) 细菌的种内和种间信息交流。乳酸杆菌(Lactobacillus) 是一种存在于人体内的益生菌,具有抑制病原微生物、维持肠道微生态平衡和增强机体免疫力等生理功能。综述了AI-2/LuxS QS 系统介导Lactobacillus 耐酸、抑制病原微生物、对肠表皮细胞的黏附和形成生物膜以及在动物消化道中的存活性等益生特性方面的分子机制。
 
The research advances of AI-2/LuxS quorum sensing system mediating
    Lactobacillus probiotic properties
JIANG Li-Ming, KANG Zi-Teng, LIU Chen-Jian, LI Xiao-Ran, LUO Yi-Yong*
(Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China)
Quorum sensing (QS) is a form of bacterial cell-cell communication through production and perception of chemical signal molecules. The informational molecules can be divided into four categories: oligopeptides, acylhomoserine lactone (AHL), autoinducers-2 (AI-2) and diffusible signal factor (DSF). Among them, AI-2 and its synthase LuxS constitute the AI-2/LuxS QS system, which mediates the intraspecies and interspecies information communication among gram-positive bacteria (G+) and gram-negative bacteria (G-). Lactobacillus is a family of probiotics which exist in the human body, possess physiological characteristics of inhibiting pathogenic microorganisms, maintaining intestinal micro-ecological balance and enhancing the immunity of body, and etc. This article reviews the role and molecular mechanisms of the AI-2/LuxS system in the regulation of acid tolerance, inhibition of pathogenic microorganisms, adhesion and colonization to intestinal epithelial cells, formation of biofilm, and viability in the digestive tract of animals of Lactobacillus.
 
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